(please send job postings to Kevin Gardner (Kevin.Gardner@icmrbs.org) for addition to this list; all postings will be limited to display for 90 days)
Scientist, Protein Pathways in Cancer Biology – Princess Margaret Cancer Centre, Toronto, Canada
The Princess Margaret Cancer Centre at the University Health Network (UHN), in conjunction with the Structural Genomics Consortium, is seeking an outstanding early career scientist with a research program in Protein Science – broadly defined – focused on e.g. protein structure, function, signalling pathways and/or networks in cancer. Candidates with a focus on protein-small molecule interactions, chemical probes and/or biological chemistry are particularly encouraged to apply. The successful candidate will have an outstanding research track record, and will be expected to develop an independent world-class research program.
As a Scientist at the Princess Margaret Cancer Centre in Toronto, Canada, the candidate will have access to extensive expertise and resources in protein-focused research, including state-of-the-art structural biology (cryo-EM, high throughput X-ray crystallography, high field NMR spectroscopy), proteomics, high throughput screening facilities and extensive biophysical methodologies for protein and enzyme analyses. The successful candidate will also be part of the University of Toronto – affiliated Protein Science community and the Temerty Faculty of Medicine, which includes other world-class institutes such as the Ontario Institute for Cancer Research, the Donnelly Centre for Cellular and Biomolecular Research, the Hospital for Sick Children, and the Lunenfeld-Tanenbaum Research Institute.
About the Princess Margaret Cancer Centre at UHN
Based in the heart of the vibrant and diverse city of Toronto, the Princess Margaret Cancer Centre is home to over 300 faculty clinicians and scientists and is one of the world’s top cancer research institutes. The Princess Margaret is world-renowned for ground-breaking cancer discoveries in stem cells, genetics and epigenetics, and immune oncology. With over 400,000 patient visits per year, the Princess Margaret Cancer Centre also has a vibrant clinical research program, evaluating novel therapeutics with deep correlative studies, and a basic research program developing and applying cutting-edge technologies to study the multiple facets of carcinogenesis and therapy response.
The successful candidate will be eligible for appointment at the Assistant Professor level in the Department of Medical Biophysics or related departments at the University of Toronto. Compensation for this position will be commensurate with experience and be consistent with UHN compensation policy. The full-time permanent position is available immediately, but the search will remain open until the position is filled.
• PhD, MD or equivalent
• Extensive experience in one or more experimental methodologies to study proteins Track record that demonstrates high impact publications, disseminating research at formal scientific meetings, and participation in the education and supervision of students and trainees
• Strong leadership skills
• Effective communication (written and verbal), problem-solving and consensus building skills
• Excellent organization, interpersonal and time management skills
If you are interested, please apply and attach your complete academic curriculum vitae (CV), covering letter and a two-page research proposal with a focus on protein-focused cancer medicine highlighting the major themes of research to be completed over the next five years, including a statement on long-term goals. You will also be required to complete some initial screening questions.
Vaccines (COVID-19 and others) are a requirement of the job unless you have an exemption on a medical ground pursuant to the Ontario Human Rights Code.
Posted Date: June 20, 2022 Closing Date: Until filled
UHN is a respectful, caring, and inclusive workplace. We are committed to championing accessibility, diversity and equal opportunity. All qualified candidates are encouraged to apply.
UHN thanks all applicants, however, only those selected for an interview will be contacted. UHN recognizes that scholars have varying career paths and that career interruptions due to personal circumstances can be part of an excellent academic record. Search committee
members have been instructed to give careful consideration to, and be sensitive to the impact of, career interruptions in their assessments.
NMR Facility Director – School of Chemistry & Biochemistry, Georgia Tech, Atlanta, GA
The SCHOOL OF CHEMISTRY & BIOCHEMISTRY of the GEORGIA INSTITUTE OF TECHNOLOGY invites applications for its NMR Center Director–Solutions Spectroscopy (Senior Research Scientist) position. Georgia Tech’s recently upgraded campus-wide multiuser facility houses several NMR spectrometers, including high-field Bruker Avance IIIHD 700 MHz and Bruker Avance IIIHD 800 MHz instruments equipped with cryoprobes, located in the Molecular Sciences and Engineering Building. The School has vibrant undergraduate and graduate programs, with over 350 undergraduate majors and 170 graduate students, and an extensive research portfolio. Its faculty, staff, and students participate in a range of dynamic and collaborative research programs and enjoy modern facilities located on a pleasant urban campus in the City of Atlanta, Georgia.
Priority will be given to applicants with expertise in biomolecular solution NMR spectroscopy. Primary responsibilities will be to maintain and troubleshoot the operation of NMR spectrometers at Georgia Tech, assist in user training, collaborate with internal and external researchers, and aid experimental design, implementation, and analysis of biomolecular magnetic resonance data. Typical experiments will include analysis of small molecules, biomolecular interactions, ligand screening, and structure determination. The successful candidate will interact with a diverse group of scientists within Atlanta’s vibrant chemical and structural biology community and foster the development of collaborative projects aiming to characterize important therapeutic targets through the Atlanta NMR Consortium.
Anticipated responsibilities include, but are not limited to:
- Monitor operational status of several high-field NMR spectrometers, oversee the performance of cryogen fills, maintain cryoprobes, and keep logs of instrument performance parameters. The candidate will be responsible for supervising several solution NMR instruments, including Bruker Avance IIIHD 800, Bruker Avance IIIHD 700, Bruker Avance IIIHD 500 (Prodigy probe), Bruker Avance IIIHD 500 (solutions and solids), Bruker Avance III 400, Varian Mercury 400, and Varian Mercury 300 spectrometers. The candidate will work closely with the NMR Center Director–Solid State Spectroscopy.
- Implement protocols and checklists for safe use of the instruments.
- Organize user scheduling for the instruments.
- Organize operational and user costs for the instruments.
- Plan, design, and oversee collaborative NMR projects for the broader biomedical research community at Georgia Tech focused on small molecules and biomolecules (proteins, nucleic acids, lipids, carbohydrates, and macromolecular complexes). The candidate will work closely with faculty spanning multiple departments at Georgia Tech, such as the School of Chemistry and Biochemistry, the School of Biological Sciences, and the School of Chemical & Biomolecular Engineering.
- Engage with leading academic/industry partners and help bring in external collaborations with nearby institutions, such as Emory University and Georgia State University.
- Train students and postdocs in small molecule and biomolecular NMR methods.
- Assist users with recording, analysis, and interpretation of solution NMR data.
- Assist in the preparation of grants to support the NMR center.
- Implementation of 1D NMR experiments (19F NMR, CPMG, STD, WaterLOGSY, etc).
- Implementation of 2D and pseudo 2D NMR experiments (HSQC, TROSYs, HMQC, HMBC, NOESY, TOCSY, CPMG, CEST, RDCs, Relaxation and dispersion, etc).
- Implementation of 3D and higher order (nD) NMR experiments (NOESY, TOCSY, HNCA, HNCB, HNCO, Non-Uniform Sampling, etc).
This job requires effective interpersonal and communication skills with the ability to work with a wide range of constituencies in a diverse community. Strong mentoring skills are a plus. The work typically requires sitting at a desk or table with occasional lifting 25 lb. or less.
- A Master’s degree and seven (7) years of relevant full-time experience after completion of that degree; or
- A Master’s degree and nine (9) years of relevant full-time experience after completion of a Bachelor’s degree; or
- Ph.D. and four (4) years of relevant full-time experience after completion of a Bachelor’s degree.
- Ph.D. in physics, chemistry, biochemistry, or a related field with 3-5 years of related biomolecular NMR experience.
- Proficiency in operating and maintaining Bruker NMR spectrometers equipped with cryoprobes and Avance consoles, as well as Varian NMR spectrometers equipped with Mercury consoles.
- Familiarity with Linux-based systems and NMR data processing and analysis tools (i.e. Topspin, nmrPipe, NMRbox, NMRFAM-SPARKY)
- Fluency in the Bruker and Varian pulse programming language, ability to implement experiments from the primary literature.
- Expertise in small molecule and biomolecular structure determination, interacting mapping, drug screening, and analysis of dynamics.
- Experience with liquid helium recycling system is highly desired.
Required Documents to Attach
- Curriculum vitae
- Cover letter
- Statement of research interest;
- 3-5 letters of recommendation send via email to Dr. Jake Soper at: email@example.com
For additional information contact Prof. Jake Soper, Associate Chair for Operations (firstname.lastname@example.org).
The position will be available beginning Nov. 1, 2022.
Equal Employment Opportunity
Georgia Tech provides equal opportunity to all faculty, staff, students, and all other members of the Georgia Tech community, including applicants for admission and/or employment, contractors, volunteers, and participants in institutional programs, activities, or services. Georgia Tech complies with all applicable laws and regulations governing equal opportunity in the workplace and in educational activities. Georgia Tech prohibits discrimination, including discriminatory harassment, on the basis of race, ethnicity, ancestry, color, religion, sex (including pregnancy), sexual orientation, gender identity, national origin, age, disability, genetics, or veteran status in its programs, activities, employment, and admissions. This prohibition applies to faculty, staff, students, and all other members of the Georgia Tech community, including affiliates, invitees, and guests.
Postdoctoral Associate – Baum Lab, Rutgers University, Dept of Chemistry and Chemical Biology, Piscataway, NJ
The laboratory of Dr. Jean Baum at Rutgers University is seeking highly motivated candidates for an NIH-funded postdoctoral position available immediately. Current projects include investigation of molecular mechanisms of protein aggregation, amyloid formation and liquid- liquid phase separation involved in neurodegeneration. The lab uses a multifaceted approach that integrates advanced biomolecular solution- and solid-state NMR spectroscopy, AFM, and other biophysical techniques with molecular biology, cellular assays, and computational methods. This allows us to probe key interactions and dynamics across a range of spatial dimensions, from the atomic level to the nanoscale. Further details can be found at: baum.rutgers.edu. Facilities include the Rutgers High Field NMR Facility, which houses four high field NMR spectrometers with state-of-the-art capabilities for solution and solid-state NMR applications, a state-of the art Cypher atomic force microscope with real-time imaging capabilities and a SYNAPT ion- mobility mass spectrometer.
The ideal candidate will be experienced in biomolecular NMR (solution and/or solid state) and other biophysical techniques and should have the ability to work independently and as part of a team. The Baum lab is highly interdisciplinary with collaborators with expertise in computational chemistry, protein design, mammalian and yeast cell culture in the School of Arts and Sciences, School of Engineering and Rutgers Biomedical Health Sciences. Applicants should email Dr. Jean Baum at email@example.com and include a CV, the names and contact information for three referees, and a cover letter describing their qualifications, research experience, and interest in the lab.
- Ph.D. in Chemistry, Biophysics, Structural Biology, or other related scientific discipline.
- Demonstrated experience in biomolecular NMR (solution and/or solids) and other biophysical techniques including AFM and mass spec.
- Proficiency in recombinant protein expression and purification from E. coli.
- Excellent organizational and project management skills.
- An excellent record of publication.